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Quinaglute Dura-Tabs

Generic Name: quinidine (KWIH nih deen)
Brand Names: Quin-Release, Quinaglute Dura-Tabs, Quinidex Extentabs

What is quinidine?

Quinidine affects the way that the heart beats.

Quinidine is used to treat irregular heartbeat patterns.

Quinidine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about quinidine?

Contact your doctor immediately if you experience ringing in the ears, changes in vision, dizziness, fainting, a rapid heartbeat, headache, nausea, a rash, or difficulty breathing.

What should I discuss with my healthcare provider before taking quinidine?

Before taking quinidine, tell your doctor if you have

• had an allergic reaction or the development of blood problems (e.g., thrombocytopenic purpura) due to previous treatment with quinidine or quinine;

• any other type of heart disease or heart problems;

• liver disease;
• kidney disease; or
• myasthenia gravis (a nerve-muscle disorder).

You may not be able to take quinidine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

How should I take quinidine?

Take quinidine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

It is important to take quinidine regularly to get the most benefit.

Your doctor may want you to have blood tests or other medical evaluations during treatment with quinidine to monitor progress and side effects.

Grapefruit and grapefruit juice may interact with quinidine. The interaction could lead to potentially adverse effects. You should discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication. A double dose could be dangerous.

What happens if I overdose?

Symptoms of a quinidine overdose include confusion, tiredness, seizures, difficulty breathing, fainting, a rapid heartbeat, and coma.

What should I avoid while taking quinidine?

Grapefruit and grapefruit juice may interact with quinidine. The interaction could lead to potentially adverse effects. You should discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Quinidine side effects

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

• a new or a worsening irregular heartbeat pattern;

• chest pain or chest discomfort;

• ringing in the ears;

• changes in vision;

• dizziness, fainting, or headache;

• rash;

• difficulty breathing;

• abdominal pain, nausea, or vomiting; or

• yellowing of the skin or eyes.

Other, less serious side effects may be more likely to occur. Continue to take quinidine and talk to your doctor if you experience

• mild upset stomach;

• headache;

• decreased appetite;

• diarrhea; or

• muscle weakness.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect quinidine?

Before taking quinidine, tell your doctor if you are taking any of the following medicines:

• pimozide (Orap);

• itraconazole (Sporanox);

• ziprasidone (Geodon);

• voriconazole (VFEND);

• thioridazine (Mellaril) or mesoridazine (Serentil);

• ritonavir (Norvir);

• dolasetron (Anzemet);

• digoxin (Lanoxin);

• warfarin (Coumadin);

• erythromycin (E-Mycin, Eryc, E.E.S., others);

• sparfloxacin (Zagam), levofloxacin (Levaquin), grepafloxacin (Raxar), gatifloxacin (Tequin);

• another medicine to treat irregular heartbeats such as bepridil (Vascor), dofetilide (Tikosyn), procainamide (Procan SR, Procanbid, Pronestyl), disopyramide (Norpace), and others;

• a beta-blocker such as atenolol (Tenormin), metoprolol (Lopressor), propranolol (Inderal), and others;

• a tricyclic antidepressant such as amitriptyline (Elavil), doxepin (Sinequan), clomipramine (Anafranil), imipramine (Tofranil), others; or

• a phenothiazine such as chlorpromazine (Thorazine), promethazine (Phenergan, Promethegan), prochlorperazine (Compazine), and others.

You may not be able to take quinidine, or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.

Many drugs other than those listed here can interact with quinidine, resulting in dangerous side effects and/or decreased effectiveness. Do not take any other prescription or over-the-counter medications, including herbal products, during treatment with quinidine without first talking to your doctor or pharmacist.

Where can I get more information?

• Your pharmacist has more information about quinidine written for health professionals that you may read.

What does my medication look like?

Quinidine is available with a prescription under several brand and generic names. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Quinora 300 mg--round, white tablets

• Quinidex Extentabs 300 mg--round, white, sustained-release tablets

• Quinaglute Dura-Tabs 324 mg--round, white, sustained-release tablets

• Cardioquin 275 mg--round, white, scored tablets

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.